Salesforce Commerce Cloud caters to large size businesses.
Shopify is suitable for small and medium sized businesses.
SFCC is backed by open architecture and API first approach.
Shopify is a user friendly multi channel commerce platform.
SFCC's advanced integration capabilities shows high scalability.
Shopify is highly scalable but not suitable for rapidly scaling businesses with high traffic.
SFCC allows integration with native products and 3rd-party systems.
Shopify has variety of plugins enabling you to integrate with third party applications.